Objective: Imbalances of the electrolyte concentration levels in the body can lead to catastrophic consequences, but accurate and accessible measurements could improve patient outcomes. While blood tests provide accurate measurements, they are invasive and the laboratory analysis can be slow or inaccessible. In contrast, an electrocardiogram (ECG) is a widely adopted tool which is quick and simple to acquire. However, the problem of estimating continuous electrolyte concentrations directly from ECGs is not well-studied. We therefore investigate if regression methods can be used for accurate ECG-based prediction of electrolyte concentrations. Methods: We explore the use of deep neural networks (DNNs) for this task. We analyze the regression performance across four electrolytes, utilizing a novel dataset containing over 290000 ECGs. For improved understanding, we also study the full spectrum from continuous predictions to binary classification of extreme concentration levels. To enhance clinical usefulness, we finally extend to a probabilistic regression approach and evaluate different uncertainty estimates. Results: We find that the performance varies significantly between different electrolytes, which is clinically justified in the interplay of electrolytes and their manifestation in the ECG. We also compare the regression accuracy with that of traditional machine learning models, demonstrating superior performance of DNNs. Conclusion: Discretization can lead to good classification performance, but does not help solve the original problem of predicting continuous concentration levels. While probabilistic regression demonstrates potential practical usefulness, the uncertainty estimates are not particularly well-calibrated. Significance: Our study is a first step towards accurate and reliable ECG-based prediction of electrolyte concentration levels.

肢体语言是一种引人注目的社交信号，其自动分析可以大大提高人工智能系统，以理解和积极参与社交互动。尽管计算机视觉在诸如头部和身体姿势估计之类的低级任务中取得了令人印象深刻的进步，但探索诸如示意，修饰或摸索之类的更微妙行为的发现尚未得到很好的探索。在本文中，我们介绍了BBSI，这是复杂的身体行为的第一组注释，嵌入了小组环境中的连续社交互动中。根据心理学的先前工作，我们在MpiigroupContraction数据集中手动注释了26个小时的自发人类行为，并具有15种不同的肢体语言类别。我们介绍了所得数据集的全面描述性统计数据以及注释质量评估的结果。为了自动检测这些行为，我们适应了金字塔扩张的注意网络（PDAN），这是一种最新的人类动作检测方法。我们使用四个空间特征的四种变体作为PDAN的输入进行实验：两流膨胀的3D CNN，颞段网络，时间移位模块和SWIN变压器。结果是有希望的，这表明了这项艰巨的任务改进的好空间。 BBSI代表了自动理解社会行为的难题中的关键作品，研究界完全可以使用。

科学数据集通常具有层次结构：例如，在调查中，个人参与者（样本）可能会分为更高级别（单位），例如其地理区域。在这些设置中，兴趣通常是在探索单位级别而不是样本级别上的结构。可以根据其平均值之间的距离进行比较，但是这忽略了样本的单位内分布。在这里，我们使用Wasserstein距离度量标准开发了一种对层次数据集进行探索性分析的方法，该指标考虑了单位内分布的形状。我们使用T-SNE构建单元的2D嵌入，基于它们之间的成对瓦斯汀距离的矩阵。距离矩阵可以通过使用高斯分布近似于每个单元来有效计算，但是我们还提供了一种可扩展的方法来计算精确的Wasserstein距离。我们使用合成数据来证明我们的Wasserstein T-SNE的有效性，并将其应用于2017年德国议会选举的数据，将投票站视为样本和投票区。结果嵌入发现数据中有意义的结构。

The release of ChatGPT, a language model capable of generating text that appears human-like and authentic, has gained significant attention beyond the research community. We expect that the convincing performance of ChatGPT incentivizes users to apply it to a variety of downstream tasks, including prompting the model to simplify their own medical reports. To investigate this phenomenon, we conducted an exploratory case study. In a questionnaire, we asked 15 radiologists to assess the quality of radiology reports simplified by ChatGPT. Most radiologists agreed that the simplified reports were factually correct, complete, and not potentially harmful to the patient. Nevertheless, instances of incorrect statements, missed key medical findings, and potentially harmful passages were reported. While further studies are needed, the initial insights of this study indicate a great potential in using large language models like ChatGPT to improve patient-centered care in radiology and other medical domains.

Cybercriminals are moving towards zero-day attacks affecting resource-constrained devices such as single-board computers (SBC). Assuming that perfect security is unrealistic, Moving Target Defense (MTD) is a promising approach to mitigate attacks by dynamically altering target attack surfaces. Still, selecting suitable MTD techniques for zero-day attacks is an open challenge. Reinforcement Learning (RL) could be an effective approach to optimize the MTD selection through trial and error, but the literature fails when i) evaluating the performance of RL and MTD solutions in real-world scenarios, ii) studying whether behavioral fingerprinting is suitable for representing SBC's states, and iii) calculating the consumption of resources in SBC. To improve these limitations, the work at hand proposes an online RL-based framework to learn the correct MTD mechanisms mitigating heterogeneous zero-day attacks in SBC. The framework considers behavioral fingerprinting to represent SBCs' states and RL to learn MTD techniques that mitigate each malicious state. It has been deployed on a real IoT crowdsensing scenario with a Raspberry Pi acting as a spectrum sensor. More in detail, the Raspberry Pi has been infected with different samples of command and control malware, rootkits, and ransomware to later select between four existing MTD techniques. A set of experiments demonstrated the suitability of the framework to learn proper MTD techniques mitigating all attacks (except a harmfulness rootkit) while consuming <1 MB of storage and utilizing <55% CPU and <80% RAM.

Mixtures of von Mises-Fisher distributions can be used to cluster data on the unit hypersphere. This is particularly adapted for high-dimensional directional data such as texts. We propose in this article to estimate a von Mises mixture using a l 1 penalized likelihood. This leads to sparse prototypes that improve clustering interpretability. We introduce an expectation-maximisation (EM) algorithm for this estimation and explore the trade-off between the sparsity term and the likelihood one with a path following algorithm. The model's behaviour is studied on simulated data and, we show the advantages of the approach on real data benchmark. We also introduce a new data set on financial reports and exhibit the benefits of our method for exploratory analysis.

We consider a semi-supervised $k$-clustering problem where information is available on whether pairs of objects are in the same or in different clusters. This information is either available with certainty or with a limited level of confidence. We introduce the PCCC algorithm, which iteratively assigns objects to clusters while accounting for the information provided on the pairs of objects. Our algorithm can include relationships as hard constraints that are guaranteed to be satisfied or as soft constraints that can be violated subject to a penalty. This flexibility distinguishes our algorithm from the state-of-the-art in which all pairwise constraints are either considered hard, or all are considered soft. Unlike existing algorithms, our algorithm scales to large-scale instances with up to 60,000 objects, 100 clusters, and millions of cannot-link constraints (which are the most challenging constraints to incorporate). We compare the PCCC algorithm with state-of-the-art approaches in an extensive computational study. Even though the PCCC algorithm is more general than the state-of-the-art approaches in its applicability, it outperforms the state-of-the-art approaches on instances with all hard constraints or all soft constraints both in terms of running time and various metrics of solution quality. The source code of the PCCC algorithm is publicly available on GitHub.

The future of population-based breast cancer screening is likely personalized strategies based on clinically relevant risk models. Mammography-based risk models should remain robust to domain shifts caused by different populations and mammographic devices. Modern risk models do not ensure adaptation across vendor-domains and are often conflated to unintentionally rely on both precursors of cancer and systemic/global mammographic information associated with short- and long-term risk, respectively, which might limit performance. We developed a robust, cross-vendor model for long-term risk assessment. An augmentation-based domain adaption technique, based on flavorization of mammographic views, ensured generalization to an unseen vendor-domain. We trained on samples without diagnosed/potential malignant findings to learn systemic/global breast tissue features, called mammographic texture, indicative of future breast cancer. However, training so may cause erratic convergence. By excluding noise-inducing samples and designing a case-control dataset, a robust ensemble texture model was trained. This model was validated in two independent datasets. In 66,607 Danish women with flavorized Siemens views, the AUC was 0.71 and 0.65 for prediction of interval cancers within two years (ICs) and from two years after screening (LTCs), respectively. In a combination with established risk factors, the model's AUC increased to 0.68 for LTCs. In 25,706 Dutch women with Hologic-processed views, the AUCs were not different from the AUCs in Danish women with flavorized views. The results suggested that the model robustly estimated long-term risk while adapting to an unseen processed vendor-domain. The model identified 8.1% of Danish women accounting for 20.9% of ICs and 14.2% of LTCs.

Linear partial differential equations (PDEs) are an important, widely applied class of mechanistic models, describing physical processes such as heat transfer, electromagnetism, and wave propagation. In practice, specialized numerical methods based on discretization are used to solve PDEs. They generally use an estimate of the unknown model parameters and, if available, physical measurements for initialization. Such solvers are often embedded into larger scientific models or analyses with a downstream application such that error quantification plays a key role. However, by entirely ignoring parameter and measurement uncertainty, classical PDE solvers may fail to produce consistent estimates of their inherent approximation error. In this work, we approach this problem in a principled fashion by interpreting solving linear PDEs as physics-informed Gaussian process (GP) regression. Our framework is based on a key generalization of a widely-applied theorem for conditioning GPs on a finite number of direct observations to observations made via an arbitrary bounded linear operator. Crucially, this probabilistic viewpoint allows to (1) quantify the inherent discretization error; (2) propagate uncertainty about the model parameters to the solution; and (3) condition on noisy measurements. Demonstrating the strength of this formulation, we prove that it strictly generalizes methods of weighted residuals, a central class of PDE solvers including collocation, finite volume, pseudospectral, and (generalized) Galerkin methods such as finite element and spectral methods. This class can thus be directly equipped with a structured error estimate and the capability to incorporate uncertain model parameters and observations. In summary, our results enable the seamless integration of mechanistic models as modular building blocks into probabilistic models.

With more and more data being collected, data-driven modeling methods have been gaining in popularity in recent years. While physically sound, classical gray-box models are often cumbersome to identify and scale, and their accuracy might be hindered by their limited expressiveness. On the other hand, classical black-box methods, typically relying on Neural Networks (NNs) nowadays, often achieve impressive performance, even at scale, by deriving statistical patterns from data. However, they remain completely oblivious to the underlying physical laws, which may lead to potentially catastrophic failures if decisions for real-world physical systems are based on them. Physically Consistent Neural Networks (PCNNs) were recently developed to address these aforementioned issues, ensuring physical consistency while still leveraging NNs to attain state-of-the-art accuracy. In this work, we scale PCNNs to model building temperature dynamics and propose a thorough comparison with classical gray-box and black-box methods. More precisely, we design three distinct PCNN extensions, thereby exemplifying the modularity and flexibility of the architecture, and formally prove their physical consistency. In the presented case study, PCNNs are shown to achieve state-of-the-art accuracy, even outperforming classical NN-based models despite their constrained structure. Our investigations furthermore provide a clear illustration of NNs achieving seemingly good performance while remaining completely physics-agnostic, which can be misleading in practice. While this performance comes at the cost of computational complexity, PCNNs on the other hand show accuracy improvements of 17-35% compared to all other physically consistent methods, paving the way for scalable physically consistent models with state-of-the-art performance.